[2] The station is also served by state-owned company Trenes Argentinos Cargas which runs freight trains in the region.

Mendoza was one of the stations that connected the Cuyo region with the city of Buenos Aires[1][6] until 1993 when the administration led by Carlos Menem closed all the long-distance passenger train services.

The Mendoza station was partially refurbished to operate the service, but works did not include the main building, which remained abandoned and vandalised.

[1] When the provincial government started works to extend the Metrotranvía line to the city of Panquehua in Las Heras Department at a cost of AR$224 million in 2014, the original building of Mendoza station was completely refurbished.

Although works were intended to be completed in 2016,[9] the station was not finished until 2019,[5] when the Mendoza – Panquehua section was inaugurated.