The station was originally built by British-owned Buenos Aires and Rosario Railway in 1889, being inaugurated two years later.

On March 10, 1993, president Menem signed the decree for which all the long distance passenger services were definitely closed, with Santa Fe being included among them.

Trenes de Buenos Aires (that had taken over the operation of Mitre Line in 1995) started to run long-distance trains to Santa Fe Province.

[2][3] Services to Santa Fe ceased in 2007 and Following a commuter train accident on February 22, 2012, at Once Station, Buenos Aires, in which 51 people died and at least 703 people were injured,[4] TBA was placed under federal intervention on February 28; its concessions to operate the Mitre and Sarmiento lines were ultimately revoked on May 24.

[5] In 2008, the Municipality of Santa Fe announced that the station building would be used to host all the street fairs of the city,[6] although it was also used for cultural activities.