[1][2] Another example is the dhurrin synthesis pathway in sorghum, in which the enzymes assemble as a metabolon in lipid membranes.
The concept of structural-metabolic cellular complexes was first conceived in 1970 by A. M. Kuzin of the USSR Academy of Sciences,[4] and adopted in 1972 by Paul A. Srere of the University of Texas for the enzymes of the citric acid cycle.
[5] This hypothesis was well accepted in the former USSR and further developed for the complex of glycolytic enzymes (Embden-Meyerhof-Parnas pathway) by B.I.
[13] In Chaetomium thermophilum, a complex of a metabolon exists between fatty acid synthase and a MDa carboxylase,[14] and was observed using chemical cross-linking coupled to mass spectrometry and visualized by cryo-electron microscopy.
The Fatty acid synthesis metabolon in C. thermophilum is highly flexible, and although a high-resolution structure of Fatty acid synthase was possible, the metabolon was highly flexible, hindering high-resolution structure determination.