[3] SAM is also involved in gene transcription, cell proliferation, and production of secondary metabolites.

[4] Hence SAM synthetase is fast becoming a drug target, in particular for the following diseases: depression, dementia, vacuolar myelopathy, liver injury, migraine, osteoarthritis, and as a potential cancer chemopreventive agent.

[6] This enzyme catalyses the following chemical reaction A computational comparative analysis of vertebrate genome sequences have identified a cluster of 6 conserved hairpin motifs in the 3'UTR of the MAT2A messenger RNA (mRNA) transcript.

[7] The S-adenosylmethionine synthetase enzyme is found in almost every organism bar parasites which obtain AdoMet from their host.

[6] The precise function of the central domain has not been fully elucidated, but it is thought to be important in aiding catalysis.