Methylliberine is an isolate of coffee beans, tea, cola nuts, guarana, cocoa, and yerba mate.

Based on its structural similarity to caffeine and theacrine methylliberine is widely believed to be an adenosine receptor antagonist, although as of 2023 no scientific studies have been done to confirm this action.

[2] There is no evidence that methylliberine augments dopamine receptors in a way that is distinct from caffeine, contrary to claims made by manufacturer.

[5] An interaction study showed concomitant administration of both caffeine and methylliberine increases the half-life of caffeine by about 2 fold.

[5] Safety studies of methylliberine have been conducted in rats.