Middle Branch Verdigre Creek is a 25.28 mi (40.68 km) long fourth-order tributary to Verdigre Creek in Knox County, Nebraska.

According to the Geographic Names Information System, it has also been known historically as:[1] Middle Branch Verdigre Creek rises on the Elkhorn River divide about 5 miles north-northeast of Page, Nebraska in Holt County and then flows northeast into Knox County and east to join Verdigre Creek about 3 miles southwest of Verdigre, Nebraska.

[1] Middle Branch Verdigre Creek drains 105.16 square miles (272.4 km2) of area, receives about 25.68 in/year of precipitation, has a wetness index of 495.92, and is about 4.14% forested.

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