Middle Wheeling Creek is a 15.11 mi (24.32 km) long 3rd order tributary to Little Wheeling Creek in Ohio County, West Virginia.

Middle Wheeling Creek rises about 3 miles southwest of Claysville, Pennsylvania, in Washington County and then flows west into Ohio County, West Virginia to join Little Wheeling Creek in Triadelphia.

[3] Middle Wheeling Creek drains 34.36 square miles (89.0 km2) of area, receives about 41.1 in/year of precipitation, has a wetness index of 295.46, and is about 61% forested.

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