Middlesex students entering eleventh and twelfth grades continued their education at the Bound Brook school through graduation.

[14] The 1974 team finished the season with a 9-0-1 record after winning the first Central Jersey Group II sectional title of the playoff era with a 24–6 victory against Hillsborough High School indoors at the Atlantic City Convention Hall.

[15] The 1994 team defeated four-time defending champion South River High School by a score of 14–7 to win the Central Jersey Group I title and finish the season 10–1.

[25] The team won the Greater Middlesex Conference Tournament (GMCT) Championship in 2012, with a 10–4 win over Sayreville War Memorial High School.

The team won the New Jersey State Group I championship in 2004, defeating Cedar Grove High School in the playoff finals.

[29] The boys tennis team won the Central Jersey Group I state sectional title in 2003, and in 2007 with a 3–2 win vs. Florence Township Memorial High School.

[30] The boys' basketball team won the Central Jersey Group I state sectional title in 1994, the program's first championship, with a 55–35 win against Piscataway Technical High School in the tournament final.