Bennett Biscuit Company, which operated a bakery on the Lower East Side of New York City.

Originally named "Maltoid", the biscuit was a bone-shaped treat made from minerals, meat products, and milk.

The marketing focus was also shifted from Milk-Bone being merely a dog treat to a product that promoted cleaner teeth and better breath.

[4] A box of Milk-Bone treats makes an early product placement appearance in the 1924 silent film The Tomboy, and this product was the basis for a line from the TV sitcom Cheers, spoken by George Wendt's character Norm: "It's a dog-eat-dog world and I'm wearing Milk-Bone underwear."

A box of Milk-Bone Biscuits can be seen, in cartoon form, in Mickey's Surprise Party (1939), a theatrical advertisement/cartoon short produced by Walt Disney Productions for Nabisco.