Millers Run is a tributary of Shamokin Creek in Northumberland County, Pennsylvania, in the United States.

It enters a valley and flows west-southwest for several tenths of a mile before turning west.

After a few tenths of a mile, it turns south and then northwest before reaching its confluence with Shamokin Creek.

[1] Millers Run joins Shamokin Creek 16.84 miles (27.10 km) upstream of its mouth.

[5] In April 1975, the concentrations of sodium and potassium in the filtered water of Millers Run were 2.90 and 0.80 milligrams per liter (0.00290 and 0.00080 oz/cu ft).

[5] In April 1975, the concentrations of cadmium, chromium, copper, lead, and nickel in the filtered waters of Millers Run were all less than 2 micrograms per liter (2.0×10−6 oz/cu ft).

[5] The bicarbonate concentration of Millers Run was measured to be 8 milligrams per liter (0.0080 oz/cu ft) in April 1975.

[3] Millers Run was entered into the Geographic Names Information System on August 2, 1979.

[6] A concrete slab bridge carrying State Route 2016 over Millers Run was built in 1918.

In 1929, a concrete stringer/multi-beam or girder bridge carrying State Route 2018 was constructed across the stream 2 miles (3.2 km) northwest of Bear Gap.