Minami-Yono Station (南与野駅, Minami-Yono-eki) is a passenger railway station on the Saikyō Line located in Chūō-ku, Saitama, Saitama Prefecture, Japan, operated by the East Japan Railway Company (JR East).

[1] Minami-Yono Station is served by the Saikyō Line which runs between Ōsaki in Tokyo and Ōmiya in Saitama Prefecture.

Additional passing tracks lie on either side of the station for non-stop rapid services.

The tracks of the Tōhoku Shinkansen also run adjacent to this station, on the west side.

[2] The station used to have a "Midori no Madoguchi" staffed ticket office, but this closed on 31 October 2007.