Located in western Saitama Prefecture, Misato is on the central reaches of the Arakawa River and is approximately 70 kilometers from downtown Tokyo.

Saitama Prefecture Misato has a humid subtropical climate (Köppen Cfa) characterized by warm summers and cool winters with light to no snowfall.

Mastuhisa, Ozawa and Higashikodama villages were created within Naka District, Saitama with the establishment of the modern municipalities system on April 1, 1889.

Misato has a mayor-council form of government with a directly elected mayor and a unicameral town council of 13 members.

In terms of national politics, the town is part of Saitama 11th district of the lower house of the Diet of Japan.