Mission Creek is a tributary, roughly 9 miles (14 km) long, of Champoeg Creek in Marion County in the U.S. state of Oregon.

The creek arises southwest of St. Paul in the French Prairie region of the Willamette Valley and flows generally northeast to meet Champoeg Creek near Champoeg.

The combined streams then flow less than 1 mile (1.6 km) before entering the Willamette River, 45 miles (72 km) from its confluence with the Columbia River.

[3][4] From its source on French Prairie southwest of St. Paul, the creek flows northeast, passing under River Road Northeast and then under Oregon Route 219 just east of St. Paul.

It joins Champoeg Creek in the Champoeg State Heritage Area, a short distance from the larger creek's confluence with the Willamette River.