It heads southeast, concurrent with MS 8, as a four-lane divided highway through a major business district, where it has an intersection with South Street, before narrowing to an undivided highway to curve eastward and pass through neighborhoods.

The highway has an intersection with U.S. Route 51 (US 51) before traveling along the southern side of downtown for several blocks to cross a bridge over Batupan Bogue.

They now pass through the neighborhood of Futheyville, where MS 333 Scenic splits off and heads north as a two-lane road.

It almost immediately has an intersection with Old Highway 8 (which provides access to nearby Hugh White State Park) where MS 333 ends, and MS 333 Scenic leaves the Grenada city limits winding its way north through some hilly woodlands for a few miles (passing by a civil war era confederate fort) to cross the dam's spillway (inadvertently also crossing the Yalobusha River) before having its first intersection with Toe Road (provides access to MS 332) before passing directly over top of Grenada Dam.

The highway has another intersection with Toe Road as it passes by the North Abutment Campground before leaving the dam area and winding its way through hilly, wooded terrain for the next several miles.