Monaco competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016.

Since the nation's official debut in 1920, Monegasque athletes have appeared in every edition of the Summer Olympic Games throughout the modern era, except for three occasions.

[2] Middle-distance runner and London 2012 Olympian Brice Etès (men's 800 m) served as the nation's flag bearer and the only Monegasque athlete to lead the delegation in the opening ceremony, as both artistic gymnast Kevin Crovetto and judoka Yann Siccardi decided to prepare for their competition on the first day of the Games.

[3][4] Monaco has received an invitation from the Tripartite Commission to send a male gymnast to the Games, signifying the nation's Olympic return to the sport for the first time since 1920.

[5] Monaco has received an invitation from the Tripartite Commission to send a judoka competing in the men's extra-lightweight category (60 kg) to the Olympics.