The rivière Moose is a tributary of lake Aylmer which is crossed by the Saint-François River which constitutes a tributary of the south shore of St. Lawrence River.

The course of the Moose River crosses the territory of the municipalities of Disraelil and Beaulac-Garthby, in the Les Appalaches Regional County Municipality (MRC), in the administrative region of Estrie, on the South Shore of the St. Lawrence River, in Quebec, Canada.

The principal neighboring watersheds of the Moose River are: The Mosse River originates between two mountains, 0.5 kilometres (0.31 mi) southeast of Lac Breeches and 1.3 kilometres (0.81 mi) southwest of route 263.

Its confluence is located 0.7 kilometres (0.43 mi) north of the confluence of the Longue Pointe stream, at 1.6 kilometres (0.99 mi) south of the confluence of the Bourgeault stream and at 2.9 kilometres (1.8 mi) (direct line) from the intersection of route 161 and route 112 at village of Beaulac-Garthby.

The toponym Rivière Moose was officially registered on December 5, 1968, at the Commission de toponymie du Québec.