It is located off the coast of Mindanao Island, and is part of the Celebes Sea.

The gulf is one of the country's tuna fishing grounds.

Zamboanga City, which is an international port, is bound by the Gulf and Celebes Sea in the East.

[3] Cotabato City, on the eastern coast, is another major port.

The Moro Gulf is also an area of significant tectonic activity with several fault zones in the region capable of producing major earthquakes and destructive local tsunamis, such as the devastating 1976 Moro Gulf earthquake which killed over 5,000 people and left over 90,000 people homeless as it hit the west coast of Mindanao.