1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A408617125ENSG00000170365ENSMUSG00000031681Q15797P70340NM_001003688NM_005900NM_008539NP_001341743NP_001341745NP_001341746NP_032565Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.

Mad mutations can be placed in an allelic series based on the relative severity of the maternal effect enhancement of weak dpp alleles, thus explaining the name Mothers against dpp.

This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses.

Alternatively spliced transcript variants encoding the same protein have been observed.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.