1DEV, 1KHX, 1U7V, 2LB3408717126ENSG00000175387ENSMUSG00000024563Q15796Q62432NM_001003652NM_001135937NM_005901NM_001252481NM_010754NM_001311070NP_001003652NP_001129409NP_005892NP_001239410NP_001297999NP_034884Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene.

SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation.

The association with SMAD4 is important for the translocation of this protein into the cell nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors.

Binding of a subgroup of TGFβ superfamily ligands to extracellular receptors triggers phosphorylation of SMAD2 at a Serine-Serine-Methionine-Serine (SSMS) motif at its extreme C-terminus.

[8] Mothers against decapentaplegic homolog 2 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.