Muhovo (Bulgarian: Мухово) is a village in Ihtiman Municipality in Sofia Province, western Bulgaria with a population of 138.

The village is located in the mountain of Sredna Gora, on the southern edge of the Topolnitsa Reservoir, at 22 km to the east of Ihtiman.

The surrounding region has a soft microclimate due to the reservoir and the southern slopes of the mountain.

Before the construction of the dam the village was located on the banks of the Topolnitsa River.

During the April Uprising the Flying Band of Georgi Benkovski passed through the villages of Oborishte, Poibrene and Muhovo.