Myocardial scarring

[2] A myocardial infarction is an ischemic event, or a restriction of blood flow to body tissue, such as by atherothrombosis.

[4] Without blood flow to the myocardium, it is deprived of oxygen, causing tissue death and irreversible damage.

[5] The tissue destroyed by the infarction is replaced with non-functioning fibrosis, restoring some of the structural integrity of the organ but resulting in impaired myocardial function.

[10]  Both the necrotic cells and the inflamed myocardium secrete and activate matrix metalloproteinase.

[10] As part of the extracellular matrix, granulated tissue consisting of fibrin, fibronectin, laminin, and glycosaminoglycan is suspended in a collagen base.