NONOate

In chemistry, a NONOate, also called a diazeniumdiolate,[1] is a compound having the chemical formula R1R2N−(NO−)−N=O, where R1 and R2 are alkyl groups.

[2][3] Almost all known examples form with the oxygen atoms cis to the double bond, which is also the thermodynamically stabler configuration.

[2][3] Most NONOates are stable in alkaline solution above pH 8.0 (e. g. 10 mM NaOH) and can be stored at −20 °C in this way for the short term.

Incubation time is important, since the different NONOates have different half-lives (t½) in phosphate buffer at pH 7.4.

This is often useful in biological systems, where a combination of different NONOates can be used to give a sustained release of nitric oxide.