Ajram rose to fame with the start of her collaboration with well-known Lebanese producer Jiji Lamara and third studio album Ya Salam.

The album's eponymous lead single "Ah W Noss" reached number one on all Arabic music charts including Lebanon and Egypt, becoming one of Ajram's internationally most successful hits of all time.

[6][7] Ajram's fifth studio album, Ya Tabtab...Wa Dallaa (2006), spawned six singles including the commercial success "Ehsas Jdeed", which topped the Arabic charts for a couple of weeks.

[9] Ajram's sixth studio album Betfakkar Fi Eih was released on July 30, 2008, after an accompanying music video that premiered on Melody Hits.

Betfakkar Fi Eih broke the record in Hit Marker's Top 10 best-selling Arabic album charts by remaining for 54 consecutive weeks in the list.

[2] The Album produced seven singles, including two promotional, which continued Ajram's reign as the artist with most number-one hits in the history of the modern Arab music industry.

A collaboration with Nancy Ajram lead to the making of the song "El Dounya Helwa" (Life Is Beautiful) for which a commercial was filmed with an American director on international standards and hi-tech effects.

However, due to Nancy's pregnancy and giving birth, she was unable to participate in the print or TV campaigns that year and the song was used on the International commercial instead.

The Arabic version "Shaggaa Bi Alamak" has Ajram featuring K'naan and meant for pan-Arab promotion of 2010 FIFA World Cup to be held in South Africa.