Lowe attended Pope High School in Marietta, Georgia, where he also played upright bass in orchestra and jazz bands.

[6] He received a midseason promotion to the Montgomery Biscuits of the Double–A Southern League, and was named to represent the Rays in the 2018 All-Star Futures Game.

[8] Lowe was named to the 2018 MLB Pipeline team of the year after hitting .330/.416/.568 with 27 home runs and 102 RBI in 130 games between the three clubs.

[14] On December 10, 2020, the Rays traded Lowe to the Texas Rangers along with Jake Guenther and Carl Chester in exchange for Heriberto Hernandez, Osleivis Basabe, and Alexander Ovalles.

[16] On June 15, 2022, Lowe became the first player to strike out in two immaculate innings in one game versus the Houston Astros.

[17] Lowe hit into 3–6 triple play in the fourth inning on August 22, lining out to Minnesota Twins first baseman José Miranda, who put out Corey Seager and threw to shortstop Carlos Correa to put out Marcus Semien at second base.

[21] On January 13, 2023, Lowe agreed to a one-year, $4.05 million contract with the Rangers for the 2023 season, avoiding salary arbitration.

However, Lowe's mom asked for him to be known as Nathaniel professionally after seeing a birthday tweet by Bally Sports Southwest calling him Nate.