The Neber rearrangement is an organic reaction in which a ketoxime is converted into an alpha-aminoketone via a rearrangement reaction.
[1][2][3] The oxime is first converted to an O-sulfonate, for example a tosylate by reaction with tosyl chloride.
Added base forms a carbanion which displaces the tosylate group in a nucleophilic displacement to an azirine and added water subsequently hydrolyses it to the aminoketone.
The Beckmann rearrangement is a side reaction.
This chemical reaction article is a stub.