The surroundings along NY 242 do not change much as it continues northeast, and after several miles and one large hill, residences become more sporadic.

Just south of the intersection of Kyler Hill Road, the route leaves Napoli and crosses into the town of Little Valley.

Now named Fair Oak Street, NY 242 crosses through the county seat into the center of the village.

[3] NY 242 continues eastward, making a gradual bend to the north into a junction with CR 88 (Baker Road).

Climbing a steep hill northeast, the route leaves Little Valley for the town of Mansfield and intersects with the other terminus of CR 15.

At the junction with Windsor Road and the summit of the hill, NY 242 bends eastward for a short stretch, entering a small residential section as the route leaves Mansfield and descends steeply toward the village of Ellicottville.

[3] US 219 and NY 242 become concurrent at the junction of Jefferson and Washington, running northeast through the village as a two-lane commercial street along the Great Valley Creek.

Paralleling the railroad tracks, the route crosses south of the hamlet of Machias, reaching an intersection with NY 16 (Main Street).