Noncovalent solid-phase organic synthesis

Noncovalent solid-phase organic synthesis (NC-SPOS) is a form of solid-phase synthesis whereby the organic substrate is bonded to the solid phase not by a covalent bond but by other chemical interactions.

As long as the reaction medium is hydrophilic (polar) in nature the anchor will remain on the solid phase.

In one experimental setup[1] the hydrophobic matrix is RP silica gel (C18) and the anchor is acridone.

Acridone is N-alkylated and the terminal alkene group is converted into an aldehyde by ozonolysis.

This compound is bonded to RP silica gel and this system is subjected to a tandem sequence of organic reactions.