North Carolina Highway 901 (NC 901) is a primary state highway in the U.S. state of North Carolina.

NC 901 is a two-lane rural highway that traverses 19.0 miles (30.6 km) from US 64, near Calahaln, to NC 115, near New Hope.

Surrounded most of its journey with farmland, NC 901 is a no-thrills road through northern Iredell County.

NC 901 is a viable alternate route between Mocksville and Wilkesboro; it is shorter in mileage, though takes a few minutes longer than via US 601 and US 421.

Established by 1930 as a new primary routing, from US 64/NC 90 to US 21/NC 26, in Harmony.