Noxubee County High School is the only public secondary school in Noxubee County, Mississippi.

[2] The Noxubee County High School football and basketball teams compete in District 4A.

The football team won the 2009 and 2012 State Championships.

[4] The Noxubee High School Tigers girls basketball team won back-to-back state titles in 1993-94.

[citation needed] As of the 2022-2023 school year, there were 416 students, 403 of whom were black, 7 of whom were Hispanic, 4 of whom were white, 1 of whom is Asian, and 1 of whom identifies as two or more races.