Ofahoma is an unincorporated community in Leake County, Mississippi, United States.

Ofahoma is located along Mississippi Highway 16 9.75 miles (15.69 km) west of Carthage.

[2] Ofahoma is a name derived from the Choctaw language meaning "Red Dog"; this name most likely was applied to a local Choctaw warrior.

[3] The community is located on the Yockanookany River and in 1900 had a population of 106.

This Leake County, Mississippi state location article is a stub.