Tuscola is an unincorporated community in Leake County, in the U.S. state of Mississippi.

Tuscola is located on the former Gulf, Mobile and Ohio Railroad and was once home to a cotton gin, three large lumber mills, and two general stores.

[2] A post office was established at Tuscola in 1872, and remained in operation until 1924.

[3] The community derives its name from the first three syllables of Tuscolameta Creek, which flows near the site.

This Leake County, Mississippi state location article is a stub.