State Route 348 (SR 348) is an east–west state highway in the south central portion of the U.S. state of Ohio.

Its western terminus is at State Route 125 approximately 6 miles (9.7 km) east of West Union, and its eastern terminus is at U.S. Route 23 just north of Lucasville – this is also the western terminus of State Route 728.

SR 348 was commissioned in 1935, routed on its current route, with the eastern terminus at its intersection with SR 73 in Otway.

[4][5] A section of SR 348 from Otway to Lucasville was originally designated a part of Corridor B on the Appalachian Development Highway System.

Only a section from U.S. Route 23 to west of SR 104 was ever completed.