From its western terminus in Scioto County, SR 776 heads east in the former Teays River valley.

It heads due north into Pike County briefly and then back due east into Jackson County, where it passes through forest patches.

It crosses the SR 32/SR 124 divided highway (the James A. Rhodes Appalachian Highway) 5 miles (8.0 km) southwest of Jackson, before ending at SR 139 less than 1 mile (1.6 km) west of downtown Jackson.

This state highway passes through portions of Scioto, Pike and Jackson Counties.

No part of SR 776 is included within the National Highway System.