From its western terminus at the interchange with Interstate 44 and Lee Boulevard in Lawton, SH-7 is a multilane highway.

It runs due east from Lawton for ten miles (16 km) before intersecting State Highway 65 in the unincorporated community of Pumpkin Center.

This concurrency ends three miles (4.8 km) south of Mill Creek, where it serves the unincorporated community of Reagan and the Slippery Falls Boy Scout Ranch.

Thirteen miles east of the concurrency, it serves the town of Wapanucka, Oklahoma, where it intersects SH-48.

[5] Along still-intact sections of SH-7, major route changes through the years include a relocation in Duncan during the early 1950s[citation needed], when the original route along Main Street through the downtown area was moved south of the business district along Bois D'Arc Avenue from US-81 eastward to tie in with the original Main Street route on Duncan's east side, which became SH-7 Alternate and now designated as SH-7 Business.

In 1969, the main Bois D'Arc Avenue alignment in Duncan was relocated slightly to the south and the rerouting continued for some 20 miles (32 km) from the SH-7/SH-7 Business junction to Velma on a new and straighter alignment (including both multi-lane divided highway and two-lane roadway) that bypassed the old SH-7 alignment through the oil fields of eastern Stephens County along with the town of Velma.

[11] It was transferred from OTA to ODOT on August 1, 2011, receiving the SH-7 Spur designation and becoming a free road.

Transferring the turnpike was considered an inexpensive way to solve the problem of excessive truck traffic in Sulphur.