The Owensboro Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of three counties in Kentucky, anchored by the city of Owensboro.

Owensboro is part of the Illinois–Indiana–Kentucky tri-state area and sometimes, albeit seldom, referred to as Kentuckiana.

As of the census[1] of 2000, there were 109,875 people, 43,232 households, and 30,142 families residing within the MSA.

The racial makeup of the MSA was 94.46% White, 3.72% African American, 0.15% Native American, 0.37% Asian, 0.02% Pacific Islander, 0.41% from other races, and 0.87% from two or more races.

Males had a median income of $33,012 versus $21,659 for females.