1BH0, 1NAU, 2G49, 2M5P, 2M5Q,%%s4ZGM, 4APD, 3IOL, 1D0R,%%s2L64, 2L63264114526ENSG00000115263ENSMUSG00000000394P01275P55095NM_002054NM_008100NP_002045NP_032126Proglucagon is a protein that is a precursor of glucagon and several other components.

It is cleaved from preproglucagon.

Proglucagon is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon.

Preproglucagon in humans is encoded by the GCG gene and is composed of 180 amino-acid residues.

More specifically, preproglucagon is cleaved into the following components in different organs: Proglucagon itself is a protein with three repeats of slightly different secretin family hormones to be cleaved to form mature hormones.