From this intersection, the route heads northeast along two-lane undivided Colebrook Road, running through rural residential areas before it comes to a bridge under the PA 283 freeway.

The route comes to a bridge over the Pennsylvania Turnpike (Interstate 76) and continues through rural land as it enters Conewago Township.

The route heads northeast into farmland with some trees and residences past this intersection.

[2][3] PA 341 enters South Londonderry Township in Lebanon County, continuing east through rural areas with some homes.

In the community of Upper Lawn, the route turns northeast to remain along Colebrook Road and runs through agricultural land with some woods.

At this time, the route was paved for a short distance east of US 230 and in the Deodate area while remainder was unpaved.