The route progresses northeast as Roseville Road, crawling through farms for a distance until the intersection with Tickner Lane, where it curves north.

Entering Rutland Township, PA 549 remains rural, curving eastward and soon southeastward into the borough of Roseville.

PA 549 forks to the northeast at an intersection with Sopertown Road, which heads into Bradford County and becomes State Route 4033.

After the intersection, PA 549 turns due north and soon to the northwest, entering the hamlet of Jobs Corners.

A short distance later, the highway enters Daggett and passes a small strip of buildings through downtown.