The road continues into Green Township and runs through a mix of farmland and woodland with a few residences, serving the community of Pine Flats.

Farther northeast, PA 580 heads into more forested areas with some fields and homes, passing through Spruce and curving to the north-northeast.

The route crosses PA 240 in Uniontown and continues through more forests.

The road turns east and crosses a R.J. Corman Railroad line, heading into the borough of Cherry Tree.

The route crosses another R.J. Corman Railroad line and the West Branch Susquehanna River, passing more homes and businesses prior to ending at US 219.