Past this interchange, PA 642 crosses into East Chillisquaque Township and becomes an unnamed road, heading through agricultural areas with some woods and homes.

The road heads into woodland and intersects the eastern terminus of PA 45, continuing through a mix of farmland and woods with homes.

The route heads through more rural areas, crossing into Valley Township and passing through the residential community of Mausdale before intersecting PA 54.

PA 642 turns northeast to fully enter West Hemlock Township and runs through more agricultural and wooded areas with occasional homes.

The route continues north concurrent with PA 44, heading through open agricultural areas with occasional residences and businesses.