The route begins at an intersection of US 119 and PA 201 in the western part of the city of Connellsville.

The route continues its concurrency with PA 381 for another 2 miles (3.2 km) until it splits at Jones Mills.

After passing through town, the route continues northeast to PA 271 in the village of Oak Grove.

In the borough of Seward, the route has a concurrency with PA 56, where it continues to Indiana County.

In the 1950s, the route’s southern terminus was moved from Pleasant Grove to PA 71 at the intersection at I-70 in the borough of Belle Vernon.