Peroxiredoxin

Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells.

Family members are now recognized to fall into six classes or subgroups, designated as Prx1 (essentially synonymous with "typical 2-Cys"), Prx5, Prx6, PrxQ, Tpx and AhpE groups.

[5] To assist with identification of new members and the subgroup to which they belong, a searchable database (the PeroxiRedoxin classification indEX) including Prx sequences identified from GenBank (January 2008 through October 2011) was generated by bioinformatics analysis and is publicly available.

[7] Using high resolution crystal structures, a detailed catalytic cycle has been derived for Prxs,[8] including a model for the redox-regulated oligomeric state proposed to control enzyme activity.

[1] Peroxiredoxins can be regulated by phosphorylation, redox status such as sulfonation,[1] acetylation, nitration, truncation and oligomerization states.

[14] Peroxiredoxin 6 knockout mice are viable and do not display obvious gross pathology, but are more sensitive to certain exogenous sources of oxidative stress, such as hyperoxia.