Piceol is a phenolic compound found in the needles and in mycorrhizal roots of Norway spruces (Picea abies).

[3] Piceol is used in the synthesis of several pharmaceutical drugs including octopamine, sotalol, bamethan, and dyclonine.

[citation needed] Piceol can be used to make acetaminophen by condensation with hydroxylamine and subsequent Beckmann rearrangement in acid.

[4] Anticonvulsants are also possible by Mannich reaction:[5] Diprenylated derivatives of piceol can be isolated from Ophryosporus macrodon.

[6] 4-Hydroxyacetophenone monooxygenase is an enzyme that transforms piceol into O-acetylhydroquinone.