He was apparently born in Siena and may have studied with Stefano di Giovanni, known as "Il Sassetta".
That same year, he worked on frescoes at the Hospital of Santa Maria della Scala (now a museum), but these have been destroyed.
In 1446, he painted the Crucifixion mural at the Siena City hall (Palazzo Pubblico) and two years later, completed another depiction of Saint Bernardino in Lucignano.
He and Vecchietta worked on а pair of reliquary shutters at Siena Cathedral; now in the Pinacoteca.
In addition to his artwork, he also provided miniatures and illustrations for various books; notably the Tractatus de Principatu (1446), now in the Biblioteca Trivulziana [it], and an Antiphonary, which is held by the Free Library of Philadelphia.