Polyamine oxidase

[6] The electron-dense aromatic ring at position 403 may interact with amino groups in the substrate.

[7] Weak interactions with other more variable active site residues are involved in positioning the substrates.

Molecules downstream of polyamine oxidation play roles in cell proliferation.

Spermidine is a precursor to hypusine, which activates eukaryotic initiation factor 5A isoform 1 (eIF5A) that enables translation of mRNA.

[12] In plants, polyamine catabolism is tied closely to stress responses and fruit ripening.

Generalized PAO reaction. R3 is a hydrogen atom, except in acetylated polyamines where it is an acetyl group.
Structure of Zea mays (corn) PAO complexed with an inhibitor and crystallized as a dimer [ 5 ]
Mechanism of Imine Hydrolysis and Cofactor Reoxidation with a Superoxide Intermediate [ 10 ]