Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA.
Cytoplasmic poly(U) polymerases can add uridine nucleotides to both coding and non-coding RNAs.
[1] Polyuridylation has been shown to play a role in gene regulation as an evolutionarily conserved process in eukaryotes.
[2] One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail.
Polyuridylation of a histone mRNA promotes its degradation, involving the exosome.