The Pongo de Mainique ('gate' in Quechua) is a water gap (canyon) of the Urubamba River in Peru.

Inside the water gap, the river is constricted to a width of 45 metres (50 yd).

The steep cliffs on each side of the river rise sharply to mountains with elevations of more than 1,200 metres (3,900 ft).

It is considered the most dangerous whitewater pass on the Urubamba; however, many boats traverse it, depending on seasonal river conditions.

According to the Wildlife Conservation Society, "the lowland rainforests and mid-montane cloud forests within a radius of five miles (8 km) of the Pongo possibly comprise the single most biologically-diverse site on the face of the Earth."