Port Isabel is a city in Cameron County, Texas, United States.

The harbor, town and lighthouse all were fought over and exchanged hands during the Civil War.

[9] On July 23, 2008 Hurricane Dolly, a category 2 storm, also caused extensive damage to the city.

Port Isabel is located in eastern Cameron County at 26°4'25" North, 97°12'48" West (26.073675, –97.213234),[10] on the western side of the south end of Laguna Madre, an estuary of the Gulf of Mexico.

The Queen Isabella Causeway crosses Laguna Madre to South Padre Island on the Gulf shore.

[6] As of the 2020 United States census, there were 5,028 people, 2,073 households, and 1,432 families residing in the city.

[27] The United States Postal Service operates the Port Isabel Post Office.

[28] Port Isabel connects with South Padre Island via the Queen Isabella Causeway.