It was formed by the merger of Medtech Products, Inc., Prestige Brands International, and the Spic and Span Company in 1996.

The company is headquartered in Tarrytown, New York[1]: 2  and operates a manufacturing facility in Lynchburg, Virginia.

[1]: 9 Among the brands owned by Prestige are Chloraseptic sore throat products, Clear Eyes, Compound W wart treatment, Dramamine motion sickness treatment, Efferdent denture care, Luden's throat drops, BC Powder and Goody's Headache Powder, Pediacare & Little Remedies children's OTC products and Beano (dietary supplement).

[7] In April 2014, Prestige Brands Holdings, Inc. announced that it has entered into a definitive agreement to acquire Insight Pharmaceuticals Corporation, a marketer and distributor of feminine care and other over-the-counter healthcare products, for $750 million in cash.

[10] In July 2021, consumer health business assets were acquired from Akorn Operating Company, LLC for $228.9 million adding TheraTears and other products to their brands.