Prince Regent spent many years as a transport, carrying troops for the British government.

British ships were then free to sail to India or the Indian Ocean under a licence from the EIC.

[3] Prince Regent's owners applied for a licence to sail to certain ports in the East Indies under the provisions for whalers.

1st convict voyage (1819–1820): Prince Regent, Captain William Anderson, departed Deal on 11 October 1819 and arrived at Port Jackson on 27 January 1820.

A news report on 17 March 1821 stated that Prince Regent had been in New Zealand waters and had gathered 1400 barrels.

On 20 July the "Prince Regent (Whaler)", Anderson, master, was at Van Diemen's Land.

2nd convict voyage (1824): Prince Regent, Wales, master, arrived at Gravesend, Kent on 3 January 1824 from Tenerife.

On 26 June 1826, Prince Regent, Richards, master, sailed from Cork to Mauritius.

3rd convict voyage (1827): Prince Regent, William Richards, master, sailed from London on 3 June 1827.

The Prince Regent is one of the best transports employed in the service, and yet she is a vessel wretchedly rigged, manned, and accommodated to her trade of carrying troops.

Out of her whole crew, there were only two able-bodied seamen; the remained having been, as usual with transports, picked up at under wages.

Some of our non-commissioned officers went on board, to distribute men to the berths as they arrived, and the filth and stench then was intolerable.